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Welcome to Biofilm Research Labs at the University of Pennsylvania
Combined treatment takes a bite out of tooth decay
Combined treatment takes a bite out of tooth decay
A game-changing synergy between ferumoxytol and stannous fluoride in treating dental caries.
New bacterial species involved in tooth decay
New bacterial species involved in tooth decay
Large study in children reveals Selenomonas sputigena as a key partner of Streptococcus in cavity formation
Highlighted by NIH Research Matters
Nanorobotic system presents new options for targeting fungal infections
Nanorobotic system presents new options for targeting fungal infections
A new way to precisely eradicate fungal infections in the mouth by using nanorobots guided by magnets.
Microbes that cause cavities can form superorganisms able to ‘crawl’ and spread on teeth
Microbes that cause cavities can form superorganisms able to ‘crawl’ and spread on teeth
Cross-kingdom partnership between bacteria and fungi with unusual strength and resilience
Ren et al. PNAS. 2022Featured by NIH/NIDCR
Shapeshifting microrobots can brush and floss teeth
Shapeshifting microrobots can brush and floss teeth
A hands-free system that automates the treatment and removal of tooth-decay-causing dental plaque
Oh & Babeer et al. ACS Nano. 2022
Featured by NIH/NIDCR
Microrobots for precision biofilm diagnostics and treatment
Microrobots for precision biofilm diagnostics and treatment
Paradigm-changing approach targets hard-to-reach anatomical spaces in an automated and tether-free manner
Babeer et al. J Dent Res. 2022
Polymicrobial aggregates in human saliva build oral biofilms
Polymicrobial aggregates in human saliva build oral biofilms
Natural consortia of microbes as "buds of growth" without orderly succession
Simon-Soro and Ren et al. mBio. 2022
Smart dental implants
Smart dental implants
Smart dental implant that resists bacterial growth and generates its own electricity through chewing and brushing
Dhall et al. ACS Appl Mater Interfaces. 2021Park et al. Adv Healthc Mater. 2020
Precision biofilm targeting
Precision biofilm targeting
Nanoparticles that target oral biofilms without disrupting microbiota and host tissues
Liu et al. Nano Lett. 2021Huang et al. Biomaterials. 2021Naha et al. ACS Nano. 2019
Affordable anti-plaque therapeutics
Affordable anti-plaque therapeutics
Ways to prevent disease which are more efficacious, sustainable and low-cost
Singh, Ren & Shi et al. Plant Biotechnol J. 2021Yuan Liu et al. Biomaterials. 2016
How bacteria build their homes on human teeth
How bacteria build their homes on human teeth
Biogeography of the polymicrobial community associated with dental caries
Kim et al. Proc Natl Acad Sci USA. 2020Kim et al. J Dent Res. 2020
Interrupting a cross-kingdom threat
Interrupting a cross-kingdom threat
The bacterial-fungal partnership that puts the disease-causing biofilm production into overdrive
Kim et al. mBio. 2021Wan et al. J Dent Res. 2021Hwang et al. PLoS Pathog. 2018
An army of microrobots can wipe out dental plaque
An army of microrobots can wipe out dental plaque
Microbe-killing robots for biofilm elimination
Hwang et al. Sci Robot. 2019
Targeting the sticky matter of plaque biofilms
Targeting the sticky matter of plaque biofilms
Dismantling the pathogenic biofilm architecture by matrix-degrading enzymes
Ren et al. J Dent Res. 2019
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